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Breakthrough Medicine

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Logo Breakthrough Medicine

Breakthrough Medicine

(9 reviews)

Finding a cure for inflammatory and vascular diseases

About Breakthrough Medicine

Sujana Biotech is developing novel therapeutics for inflammatory and vascular diseases
Binding of the leukocyte-expressed integrin macrophage-1 antigen (Mac-1) to platelet-expressed glycoprotein Ibα (GPIbα) is a key event mediating inflammation-associated transmigration of leukocytes out of the vasculature. The Scientific Founders, Dan Simon, Ed Plow, and Yunmei Wang have shown that the strong interaction between Mac-1 and GPIbα is critically dependent on a short segment of Mac-1 (termed the “M2” region). They have also demonstrated that M2 is not critical for the binding of Mac-1 to other important ligands such as fibrinogen and that selective inhibition of the GPIbα interaction through M2-directed strategies is possible without affecting Mac-1 interactions with other binding partners. These observations suggest that novel therapeutics targeting M2 may inhibit a number of pathological inflammatory conditions without compromising other innate immune or hemostatic functions.
Preclinical studies in a variety of animal models indicate that leukocyte engagement of platelet GPIbα via Mac-1 is critical for the pathophysiological response to mechanical vascular injury and also implicate the GPIbα-Mac-1 interaction in the development and progression of thrombosis, vasculitis, glomerulonephritis, and multiple sclerosis.

Collectively, the data advance the hypothesis that inflammation is broadly platelet-dependent and that therapeutic strategies directed against M2 may offer an innovative, effective approach to diverse inflammatory diseases.
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Company Info

  • Year Founded 2015
  • Number of Employees 50 - 99
  • Minimal Budget $10,000 - $25,000

Our Location

  • Tower East, Shaker Heights , Ohio 44122 , United States

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